For Palestinians, the violence in Gaza is a manifestation of pent-up frustration and anger surrounding the hope for peace.
It was the bloodiest day in the Israeli-Palestinian conflict since a 2014 Gaza war. It's unclear exactly the degree to which protesters are members of or coordinated with Hamas, but they include women and children.
Palestinian Authority President Mahmoud Abbas, however, described Trump's decision as the "slap of the century".
Israel occupied the West Bank and east Jerusalem in 1967 and later annexed east Jerusalem in a move never recognised by the worldwide community.
Israeli Prime Minister Benjamin Netanyahu defended his military's show of force and thanked President Donald Trump for keeping his promise to move the U.S. Embassy.
Since announcing his decision to move the United States embassy from Tel Aviv to Jerusalem, Trump has become the namesake for a number of subjects in Israel, including parks, streets, and a planned high-speed rail station near the Western Wall in the Old City.
His daughter Ivanka and her husband Jared Kushner attended the ceremony, as they led a U.S. delegation that included the treasury secretary and four Republican senators.
The blockade has also been marked with violent conflict between Israel and Gaza's ruling party Hamas, which is considered a terrorist group by the U.S.
"We will not allow today to be the day the Muslim world loses Jerusalem".
Both Israeli and Palestinian officials expect the death toll in Gaza to rise.
He called Monday "a day of great shame", noting that the killing of Palestinian protesters comes as "Trump celebrates the relocation of United States illegal embassy and his Arab collaborators move to divert attention".
"We are ecstatic to be able to celebrate Israel in this way", Naomi Adler, president & CEO of the Jewish Federation of Greater Philadelphia, said.
Israel, however, regards all of the city, including the eastern sector it captured in the 1967 Middle East war and annexed, as its "eternal and indivisible capital" in a move that has not won global recognition.
Alistar Burt, the UK's minister for the Middle East, said: "The violence today in Gaza and the West Bank has been shocking".
Some estimates Monday morning put the number killed at 41, and the number injured in the thousands. Israel is absolutely fighting terrorism with us and combating terrorist financing.
The protests were supposed to end on May 14, the day on the Gregorian calendar when Israel became an independent state 70 years ago, which the Arab world calls the Nakba, or catastrophe.
"What Israel has done is a genocide".
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