Osaka, who is the reigning US and Australian Open champion, saw her first career title defence go down in flames at the hands of a razor-sharp Bencic, who won their fourth-round match 6-3 6-1.
But there were no tears on Tuesday as Osaka said she was adjusting to being the world number one and always having a target on her back. She won everything in the past couple of months.
I think before I didn't realize that so much. "But I think now there is way too many videos and too many people have watched my matches".
"When I hit a good return, I was wondering why this didn't happen in singles", he said. Her triumph in Australia made her No. 1 for the first time, but her time at the top has been rocky.
World number two Simona Halep of Romania is also out, beaten 6-2 3-6 6-2 by Czech teenager Marketa Vondrousova.
"I think it's always a bit tricky whenever you change someone in the team, but I feel like for a first tournament we did really well", she said of her partnership with Jenkins, a former United States collegiate star who served as a hitting partner to Venus Williams from 2015 until the end of last season. Halep got injured during the match and received treatment for blisters on her foot. "But it's everything I could do today".
Hurkacz, unseeded, reached the fourth round of a Masters 1000 event for the first time in his career. Vondrousova, who beat 2018 runner-up Daria Kasatkina and former French Open victor Jelena Ostapenko on the way to the fourth round, will go for another big win when she faces sixth-seeded Elina Svitolina, who battled to a 7-6 (10/8), 5-7, 6-4 victory over Australian Ashleigh Barty.
Ranked 36th in the world, Venus Williams endured three sets in her first two matches.
Andreescu improved her match record for 2019 to 25-3, including qualifying, as she became the youngest player to make the last eight at Indian Wells since a 17-year-old Anastasia Pavlyuchenkova reached the semis in 2009.
In other third-round action, three-time grand slam champion Angelique Kerber came from a set down to beat Russian qualifier Natalia Vikhlyantseva 3-6, 6-1, 6-3.
She will play Spain's Garbine Muguruza next, after the former world number one beat Kiki Bertens 5-7 6-1 6-4.
"It gives me confidence that I can turn around matches, that I can play also three sets, also in the close moments that I'm there, that I can trust myself", said Kerber, adding that it was always hard to face an opponent for the first time.
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